4TH SEMESTER

The human genome: structure and function of genes and chromosomes, Tools of human molecular genetics, Principles of clinical cytogenetics, Clinical cytogenetics, Patterns of single-gene inheritance, Genetics of disorders with complex inheritance, Mutation and polymorphism, Gene mapping of human genome, Hemoglobinopahties, The molecular, biochemical and cellular basis of genetic disease, The treatment of genetic disease, Genetic aspects of development, Prenatal diagnosis, Genetic and cancer, Personalized medical genetics, Pharmacogenetics and pharmacogenomics, Genetic counseling and risk assessment.

Care Levels (Primary Health Care, Secondary and Tertiary Care), Principles of “Good Medical Practice”, Basic Principles of Healthcare Teamwork, Health Education and Promotion, Levels of prevention, Vaccines for Healthcare Workers – “Flu” Vaccine. Medical history taking and writing (with emphasis on present disease investigation) through selected scenarios. Communication with people with disabilities. Introduction to clinical examination. Intimate examination (e.g. digital rectal examination). Technical skills: Venipuncture (fluid administration, blood sampling), Injections (intravenous, intramuscular, subcutaneous), Male and female bladder catheterization, Wound dressing and suturing, Airway management, Electrocardiogram technique.

Knowledge of the anatomy of the Central Nervous System (CNS), which includes the brain and the spinal cord as well as the sensory organs, which is required for the understanding of Clinical Neurology, Neurosurgery, Clinical Ophthalmology and Otolaryngology . Goals during lectures: Detailed knowledge of the terminology, morphology and anatomical relations of the enclosed parts and function of the anatomical landmarks of the CNS. Theoretical classes: Knowledge of the basic morphological characteristics of the CNS and of the sensory organs. Goals during Practical classes: Recognition and distinction of vessels, nerves and the anatomical landmarks of the CNS and of the sensory organs onto the human body.

Students will know the stages of embryonic development, starting from the gametes until the delivery of the baby. Emphasis is placed on diagnostic methods of imaging fetal development, on monitoring development based on milestones, on the causes of congenital abnormalities formation, on placental growth and function. The development and formation of organs and systems, in addition to their most common congenital anomalies are studied.

Methods of Analysis in Clinical Biochemistry – Biochemical Data and their Clinical Evaluation – Clinical Laboratory Study and Evaluation of Bibliographic Data – Assessment of Renal Function – Calcium Metabolism – Free Radicals – Diabetes- Obesity- Lipids and Atherosclerosis – Serum Proteins and other Biological Liquids – protein disorders associated with the immune system-Hepatic Function – Hemoglobinopathies and Enzymes causing hemolytic anemia – Disorders of heme and iron metabolism- Hemostasis and coagulation disorders – Hypothalamic and pituitary hormones – Thyroid and adrenal hormones – Reproductive and pregnancy hormons- Molecular diagnosis of genetic diseases – Biochemical markers of cancer and other specific diseases – Molecular diagnosis of cancer.

Upon successful completion of the course, the student will be able to know the physiological function of nervous, digestive and endocrine system of the human body.